Elnaz FaghfuriArdabil University of Medical Sciences, Iran
Title: Cellular immunotherapy in gastric cancer
Introduction: Gastric cancer (GC) is one of the most frequently diagnosed malignancies. Recent studies have highlighted cellular immunotherapy (CI) as a promising approach for treating this disease. Among the CI-based approaches, adoptive cell therapy and dendritic cell-based vaccination are commonly studied in preclinical and clinical trials.
Search Method: Here we review the current evidence on the potentiality of CI in treating GC, the targets for adoptive cell therapy, ongoing clinical trials, constraints and the future outlook.
Results: The results suggest that there is a need to identify novel biomarkers that predict which GC patients will most likely respond to these approaches. Also, CI plus chemotherapy or immune checkpoint inhibitors can improve the survival of patients with late-stage GC.
Conclusion: Therefore, Cellular immunotherapy can be promising for treating gastric cancer patients
Elnaz Faghfuri completed her PhD at the age of 30 years from Tehran University of medical sciences, Iran. She is an assistant professor at Ardabil University of medical sciences, Iran. She has over 20 publications on cancer therapy, and his Scopus h-index is 10. She has reviewed more than 20 prestigious journal articles.