Primary GI lymphoma is a malignancy where the main bulk of disease is in the GI tract, with or without involvement of adjacent lymph nodes. GI lymphomas constitute 1 to  4% of all GI malignancies, 10  to 15% of all NHLs and 30 to 40% of all extranodal NHLs, making the GI tract the most common site of extranodal NHL. Most lymphomas of the GI tract are B-cell lymphomas. GI lymphomas most commonly involve the stomach or small intestine, although the oropharynx, esophagus, colon, or rectum may be rarely involved. In developed countries, the stomach is the most common site of GI involvement (≈60% of cases), but in the Middle East, the small intestine is the most common site of involvement.  Gastric lymphoma commonly presents with dyspepsia and epigastric pain.  Less common symptoms include anorexia, vomiting,  early satiety, weight loss, GI bleeding, fever and night sweats. Small intestinal lymphoma patients usually present with chronic diarrhea, colicky abdominal pain, anorexia, weight loss, fever and malnutrition. Sufficient tissue is required for an accurate diagnosis. In the GI tract, this means multiple endoscopic biopsies. The minimal pathologic workup should include light microscopy and immunophenotypic analysis, either by flow cytometry or immunohistochemistry. In addition to CT of the chest, abdomen, and pelvis,  EUS and laparatomy with full thickness intestinal biopsy may be required for staging of GI lymphomas. Treatment varies according to lymphoma subtype and stage. Prolonged remission can be obtained with long term antibiotic therapy but surgery -+chemotherapy/radiotherapy is required for those who have aggressive disease.  

Md Rubel Miah graduated from Dhaka Medical College, the most prestigious institute of Bangladesh in the field of medical science in 2008. Then he completed the Membership (MCPS) and Fellowship (FCPS) exam of Bangladesh’s most reputed post graduate institute, BCPS (Bangladesh College Of Physicians and Surgeons) in Medicine in January and July/2017 respectively. He pursued his  MD (Master) in Gastroenterology in 2020 from Bangabondhu Sheikh Mujib Medical University, Dhaka, Bangladesh. He received the prestigious Gold Medal Award Of BCPS from the honorable Prime Minister Of Bangladesh for outstanding performance in the Fellowship exam of Medicine. He is a Medicine specialist and gastroenterologist. He worked in Dhaka Medical College Hospital as a Consultant of Medicine for the last three years and has vast experience in dealing with Medicine and GI patients. He has expertise in Upper GI endoscopy and colonoscopy and performed more than one thousand endoscopic and colonoscopic procedures. He has a special interest in GI malignancies including Primary GI lymphoma. Currently, he is working as a Consultant of Medicine in a district hospital of Bangladesh and is also involved in teaching undergraduate and postgraduate students. He is a member of the Bangladesh Society of Medicine (BSM), Bangladesh Gastroenterology Society (BGS) and American College of Physicians (ACP). He is also involved in making the people aware of common diseases by writing in the national dailies. He has 5 publications and he is also a peer reviewer for Annals of Internal Medicine Clinical Cases of ACP.