Omar Eduardo Benavides Ayala

Fundación Hospital San Pedro, Colombia

Title: Classic biphasic pulmonary blastoma in adults: an up-date review of a rare disease

Abstract

Pulmonary blastoma Pulmonary blastoma (BP) is a rare lung cancer that accounts for a small fraction of primary lung tumors. There are around 280 cases reported in adults older than 40 years old, with a few cases reported in Latin América and the Caribbean. This tumor presents a histological heterogeneity of malignancies mixed epithelial and mesenchymal. In addition, cytokeratin and vimentin expression in the blastomatous component that provides more support for a single origin. Molecularly, it has been associated with mutations of p53 and ROS1 signaling pathways. The symptoms are non-specific, with 40% of patients asymptomatic before diagnosis. The diagnostic imaging may show signs of this disease, and a biopsy can be done through bronchoscopy or thoracoscopy. Timely diagnosis is very important given the poor prognosis of this disease. In focal lesions, a surgical approach is preferred. However, complementary therapies remain controversial due to the rarity of the disease. Researchers have investigated using radiotherapy cycles specifically for tumors that cannot be surgically removed. The combination of cyclophosphamide, vincristine, doxorubicin, and dactinomycin has been proven effective in treating this cancer. The approach and dissemination of this type of cases helps to visualize the approach and adequate treatment of this pathology that, given its rarity, the lack of knowledge can have an impact on the patient's prognosis.

Biography

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3RD INTERNATIONAL CONFERENCE ON CANCER SCIENCE AND THERAPY

(HYBRID EVENT) | MAY 06-07 , 2024 | Bangkok, Thailand

Omar Eduardo Benavides Ayala

Title: Classic biphasic pulmonary blastoma in adults: an up-date review of a rare disease

Abstract

Biography

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