According to statistics, the incidence and mortality rates of CRC rank third and second in the incidence and death spectrums, respectively, of malignant tumors. However, early diagnosis and intervention can considerably improve the quality of life and the 5-year survival rate of patients with CRC. Endoscopic treatment is feasible for colorectal precancerous lesions, M-stage cancer, and colorectal cancer confined to SM1. Therefore, an accurate judgment of tumor nature, size, and depth of invasion under endoscopy is a vital prerequisite for making tumor treatment choices. Currently, endoscopists frequently decide the treatment of colorectal polyps according to the characteristics of white light endoscopy, and polyps smaller than 2 cm usually do not receive adequate attention, leading to their inappropriate treatment. Chicken skin mucosa (CSM) surrounding colon polyps is a common endoscopic finding that could be an endoscopic predictive marker of submucosal invasion. we analyzed 198 consecutive patients with lesions smaller than 2 cm [233 early colorectal cancers(ECCs)] who underwent endoscopy or surgical procedures between January 2021 and August 2022. Logistic regression analysis show that CSM, a depressed area with clear boundaries, erosion, or ulcer bleeding, and size (≥ 10 mm) were independent risk factors for submucosal invasion in ECC. CSM has a clinicopathological value for predicting deep immersion in early colorectal carcinoma in the left colon.

Ying-Jie Zhang, MD, Doctor at the Department of Gastroenterology and Hepatology, Chengdu Second People’s Hospital, Chengdu, Sichuan Province, China. His research areas are early diagnosis and treatment of digestive tumors. His research results: Published 7 articles as the first or corresponding author in Endoscopy, World J Gastrointest Oncol, etc.